Friday, October 29, 2010

San Marc

Back to work yesterday after what one can only say was the experience of a lifetime. And I hope to go back for more.

Walking through the gate at San Nicholas, in San Marc, about 2 hours north of PAP, there was an incredible scene, that most of you have now probably seen on TV. People essentially on cots and blankets on the ground all throughout the central courtyard of the hospital and lined up side by side in each ward including the radiology building and ER. The entrance was guarded and one has to step on a foam pad soaked in bleach to enter/exit with a hand washing station there too. Orange construction webbing fences cordon off 1/2 the hospital marked as contaminated. People lined up waiting at the triage tent to either have and IV started and admitted to the hospital or else sent to an observation tent to make sure they were tolerating Oral Rehydration Solution (ORS) well enough to go home. The hospital is a partnership of MSPP (ministry of health) and Partners in Health. Once the epidemic hit, Mediciens sans Frontiers joined the partnership to run the logistics and manage strategy for the epidemic.

I worked Saturday from the AM until Sunday morning, then swapped to nights as one of 2-3 docs taking care of 300+ people in the hospital overnight. I ended up running triage up front, which ended up being an incredible job. When one hears that cholera can deplete 10-20 liters in the 1st 12-24 hours, it is really hard to imagine what that looks like. People came in all night, some looking literally like skeletons with eyes sunken in, flat temples, unconscious. One would assume that they were chronically ill, and while some were, you could literally watch people reinflate to normal people after 10 liters of IV fluid. The 1st night (about 4 days into the epidemic) so many people were coming in almost too late, nearly pulseless on arrival to the gate. Luckily as the days went on, community education was spreading and people were coming in as soon as symptoms started for the most part, and few were as sick.

Cholera, luckily is quite easy to treat. Cholera unluckily, is much harder to control and prevent on a population level when people are in crowded conditions with poor sanitation on top of baseline starvation and a high rate of previous existing illnesses that set people up for badness. It is thought that 80% infections are asymptomatic and really only 10% have the severe rice water stools and projectile vomiting with hemodynamic collapse, but we put IV fluids into 300 people daily. Not sure what the denominator is for that number, but one can assume that in a population with zero immunity (last case of Cholera on Hispanola was >50 years prior), the ratio of severe illness is higher. Treatment is simple: IV fluids until people are conscious and the vomiting has abated enough to keep fluids down, then transition to ORS until stools <3>

What is tricky, is finding veins on someone 10+ liters depleted when they are already cold to touch and with barely a carotid pulse. We had some great saves however, including one where 2 med students and myself put a peripheral IV into each limb and grabbed 4 men to squeeze bags of fluid in and delivered 8L in about 15 minutes to someone in that situation. 1mg of epinephrine helped a little too...

I already had learned how to place intraosseous lines at MGH, but we usually have a gun/drill tool that bores through the tibia. But, I learned that with a little elbow grease, one can put them in a kid without the gun, by which I mean just screwing a 16G needling into the bone until it pops through and you can pull marrow back. Each night I put 3 or so in on kids that were too dry to find veins on and were minutes from death, and in each case, were able to revive the kid!

Other highlights were meeting Sean Penn, working with PIH, getting interviewed on NBC nightly news by Nancy Snyderman, and accidentally having to deliver a breach baby on a non-cholera patient because I ran into the labor ward to get something, found a woman there was failing to make progress with a baby in trouble (compressing cord) and no obstetrician in site, so I had to just start pulling! Baby looked awful at first, blue, not crying, not moving, but after a few minutes of vigorous resuscitation, she perked right up and looked great.....wow. I have never had to do that (she would have had a C section if there had been a real obstetrician there).

There have been so few times in my still short medical career where I can honestly say to myself that I am so glad to have been there to save someone's life. In most other medical situations I am in, if I wasn't there, there would have been someone else with the manpower or the knowhow to do what needed to be done or else they would have probably done fine on their own. And nothing egotistical at all, but I can think about 10 people each night I spent there that would have died if I hadn't been there...and I mostly feel honored and humbled to have gotten to take part in the amazing colossal effort put forth by so many groups to run San Nicholas hospital as an emergency cholera center. Situation ongoing, but seems to be cooling off. Hope that the trend sticks in San Marc and that the epidemic continues to stay out of PAP for the most part. There are a few cases here, but most are friends/family of people in the Artibonite, no evidence of it in our water supplies here yet, though people are bracing (but not quite actually preparing) for that likelihood.

Friday, October 22, 2010

Cholera

Many of you have heard by now that probably 200 people died and thousands fell sick just yesterday in San Marc, Artibonite, about 70KM NW of PAP. It was only confirmed today, previously seen to be acting like Cholera, but not confirmed in the lab until today. And it is spreading like, well a Cholera epidemic. It is on the Isle of Goncave and reports are that it has reached the famous slum/suburb of PAP called Cite Soleil. I am sure it will be in PAP proper tomorrow or the next day. I'm taking a break from TB this weekend to head up with a few other folks (and a crate of alcohol, hand wash, and IV fluids) to go up to Artibonite and try to treat people since they are completely overwhelmed.

This is the feared epidemic that everyone expected after the earthquake and hadn't yet come (well, lots of typhoid, but that was more an upsurge in the endemic....) I can't imagine what will happen when it hits the city. We are not prepared....

And its sort of amazing to be part of the live reports coming in. We knew about this before it hit the papers (they were calling us to ask if we knew anything) and before it hit major health organizations....we need major mobilization here now, or there will be trouble!

If you want to send anything down, let me know, and I can direct you to the folks to donate to...

Dr. Rachelle vini nan Ayiti

Sorry all for the hiatus in posting. I think that I will be making many short posts so that I can be convinced to post more often.

So for those I haven't filled in about my work here, I am working in a semi-independent TB hospital on the grounds of l'Hopital d'Universitat du'Etat du Haiti (or the General, L'hopital General....etc) in Port-Au-Prince. It is a 6 tent unit with 70 patients, all with TB or presumed TB and 30% coinfection with HIV. A lot of our patients arrive acutely ill with oxygen saturations in the 50s and 60s (normal being of course 100%, but 90% generally considered the threshold for applying supplemental oxygen) and many of the adults are 70-80lbs after being ill for several months.

What is tough about the diagnosis of TB in PAP now is that it is really hard to grow TB in the lab and 20% or more of people never grow it despite having the disease, with this being a harder diagnosis in HIV. So most people around the world rely on the clinical syndrome for a suspected case, since confirmation often takes 1-4 weeks, if they're in the 80% with positive sputum tests. Things like weight loss, fevers, night sweats, loss of appetite, and cough (sometimes with blood) for more than 2 weeks are strong indicators.

So if you're interviewing patients in PAP, most of whom referred for suspected TB are of course very impoverished and living in tent cities, you ask" Do you have fevers?" " Do you have weight loss" Do you have a hard time eating?" Do you have night sweats?" The answer is yes. Since when "apres tremblemant la (since after the earthquake)."

Everyone has had weight loss (no work, no food, lots of depression), night sweats (hmm living in 100 degree weather in a tent) , and cough (living in rubble in a tent with open fires)....

Despite this, TB is very rewarding, because it is a lot of thinking to make the diagnosis, even if the treatment is the same for almost everyone (4 drugs in 1 fixed combination pill provided by WHO).

And even better is coming back 4 months after I was last here and seeing some of my previously starving and near-death patients, who are walking back into the clinic to pick up the last month of medication (it's a 6-24 month treatment depending on if you have resistant TB, 6-9 for most folks!)...and these skeletons are fleshed out lovely people who are happy and healthy and occasionally back to work (there's no work obviously). But there are also 8 patients still hospitalized or rehospitalized since my trip in June, so I have several friends in the tents who are excited to see the same face 4 months later. A few of these are teenagers without family who just need to hang out with us (one's on 02 still and likely forever because of his pulmonary hypertension from the TB) because they are too weak to go to a tent city somewhere.

Great to be back.